Low Endotoxin Recombinant Serum Albumin HSA Cell Culture For Vaccine Manufacture / Formulation

Low Endotoxin Recombinant Serum Albumin HSA Cell Culture For Vaccine Manufacture / Formulation

Quick detail

1. Amino Acids Sequence: Same as the HSA from plasma
2. N-terminus: DAHKSEV
3. C-terminus: KLVAASQAALGL
4. Glycosylation: No
5. PI: 4.8
6. Thermal Stability: M/P 65℃
7. Lipid Conjugation: Same as the HSA from plasma
8. Crystal Structure: Same as the HSA from plasma

Description 

There are over 20 kinds of vaccines currently used for human disease control so far. At the same time, the vaccine safety issue deserves our close attention. Healthgen Biotech provides no animal origin rHSA for vaccine production and avoids the potential risk from animal-derived proteins. rHSA can be used in the upstream cell culture, like vero and MDCK,and in the final vaccine formulation. Our scale production facility is compliant with GMP.And the rHSA has been registered in US FDA as DMF.The DMF no. is 029 648.

Advantages

1. Wuhan Healthgen Biotechnology Corp. is a private company founded in 2006. We specialize in molecular pharmaceutical technology research and high-tech innovation-oriented product development, which is developing, manufacturing and marketing a series of recombinant proteins and growth factors by rice endosperm platform. We have 400 square meters of research center, in which 30% of the research personnels have doctoral degree and major in different directions of the research and development. Healthgen has strong capability in developing a series of biological products.

2. Healthgen Biotech quality control systerm has been certified by ISO 9001:2015 and ensure standardized process as well as qualified products.

3. Recombinant human serum albumin (OsrHSA) has good efficacy, such as OsrHSA has the same second and tertiary structure, physiological and biochemical properties with HSA from plasma. In addition, compared with HSA from plasma, OsrHSA has a lower immune source stimulation, and plays a better role in accelerating cell growth and metabolism, because OsrHSA is animal component free, which can avoid the prions or virus contaminants.

Supplemental Description

Human serum albumin has been widely used as plasma expansion reagent. Because of its non-enzymatic activity and no immunogenicity, etc. HSA can also be used as excipient and stabilizer in a variety of pharmaceutical preparations and serum-free cell culture medium component. In addition, HSA is also used as a drug carrier due to its antioxidant properties, thereby conferring drugs better physicochemical properties. At present, most HSA products in the market are directly derived and refined from human plasma.

On the one hand, due to the potential existence of various infectious disease pathogens in the human blood, especially AIDS, hepatitis B and other viruses. Thereby, these virus from human plasma will be brought with HSA to the final products. OsrHSA produced by gene recombinant technology can effectlively avoid the risks of virus pollution and infection. What’s more, the supply of human blood is limited. Therefore, it’s very urgent to search blood substitutes. The establishment and development of recombinant DNA technology provide an important method for the acquisition of biological materials. In recent years, many researchers have been hotly committed to the recombinant human serum albumin research.