Excipient Grade Recombinant HSA Human Serum Albumin Powder No Stabilizer

Excipient grade recombinant human albumin powder

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Human serum albumin (HSA) is extensively used in clinics to treat a variety of diseases, such as hypoproteinemia, hemorrhagic shock, serious burn injuries, cirrhotic ascites and fetal erythroblastosis. To address supply shortages and high safety risks from limited human donors, Healthgen Biotech has developed recombinant technology to produce HSA from rice endosperm. The recombinant human albumin (OsrHSA) has excellent batch consistency. Using self-pollination rice as the bioreactor to express the OsrHSA, with the world's advanced facility and top production proceeding to extract and purify the OsrHSA, Healthgen Biotech can ensure the excellent consistency of OsrHSA from different batches.

Excipient grade recombinant human albumin displayed similar in vitro and in vivo immunogencity as plasma HSA.

• Double-cross immunoprecipitation experiments between OsrHSA or pHSA and antiserum against pHSA or rHSA showed that both OsrHSA and pHSA bound completely to antiserum against rHSA or pHSA.
• In ELISA tests, polyclonal antibodies against pHSA reacted equally with OsrHSA.
• Anti-OsrHSA serum neutralized by pHSA or OsrHSA gave a negative response compared with the saline control in the passive cutaneous anaphylaxis (PCA).

In the human peripheral blood mononuclear cells (PBMCs) model, OsrHSA does not have any drug-related immunotoxic effects and induces the same level of cytokines.

Healthgen recombinant human albumin (OsrHSA) is structurally and biochemically equivalent to pHSA