Animal Free Recombinant Serum Albumin For Bio Industry

Animal Component Free Recombinant Serum Albumin Widely Used in Bio-industrial

Description

Human serum albumin is the most abundant protein in human plasma. It can transport hormones, lipids and other molecules and maintain osmotic pressure. OsrHSA is a recombinant human serum albumin derived from rice grains, which provides an excellent solution to use an animal free material. OsrHSA has been demonstrated to be folded into the identical structure and has the same active function as plasma human serum albumin(pHSA), as well as the same immunogenicity. Currently, OsrHSA can be an excellent alternative to pHSA widely used in bio-industrial application, details as follows:

Cell culture

As an effective additive in serum-free culture media, OsrHSA can be used in:

1) Stem cell: MSC, ESC, iPSC, NSC

2) Immune cell: T cell, NK, CIK, DC

3) Vaccine upstream cell: Vero, BHK, MDCK, MRC5

4) Recombinant proteins/peptides upstream cell: CHO, HEK 293, SP2/0

When added into cell culture media, OsrHSA shows good performance in promoting cell growth and proliferation.

Cell & Gene Therapy

OsrHSA can be used in whole life process in cell and gene therapy, including upstream cell culture, cell infusion and cryopreservation in which OsrHSA can protect the cells, prevent cells from clumping, and protect cells from the hurt of shear force of rapid freezing water. Moreover, OsrHSA is also an effective virus protectant in gene therapy.

Medical devices

1) In vitro diagnosis: OsrHSA can be used in Mass spectrum diagnosis as plasma matrix control , in biochemical diagnosis and in immune diagnosis such as ELA, CLA as a blocking agent.

2) Surgery devices: OsrHSA is a good coating agent in surgery devices such as HydroGel and Tridyne^TM vascular sealant because of its good compatibility and stability.

Vaccine

OsrHSA can be used as culture media additive in upstream cell culture, virus protectant in processing and protective ingredient in the final vaccine product.

Drugs

Based on albumin hydrophobicity and stability, OsrHSA can be made into microspheres or nanoparticles as drug carrier for drug delivery. Furthermore, OsrHSA also can be used as albumin-drug conjugation, therapeutic proteins/peptides conjugation and antibody conjugation to lengthening the half-life of those drugs due to the good binding property and long half-life of albumin.

Tissue & tissue products – Stem cell

OsrHSA is an effective media additive in upstream cell culture and cell protectant in cell infusion and cryopreservation.

IVF

OsrHSA can be added into gametes and embryos cell culture media to promote cells growth and proliferation. Secondly, OsrHSA is also one ingredient in some gametes and embryos handling media. Thirdly, it can be used in gametes and embryos cryopreservation as protectant.

Advantages

OsrHSA used in bio-industrial applications has many advantages, such as:

1) Healthgen Biotech quality control system has been certified by ISO 9001:2015 and ensure standardized process as well as qualified products.

2) OsrHSA is free of animal origin, which effectively avoid any potential risk of animal bacteria, prions, virus and contagious protein disease.

3) OsrHSA has excellent batch consistency. Using self-pollination rice as the bioreactor to express the rHSA, with the world's advanced facility and top production proceeding to extract and purify the OsrHSA, Healthgen Biotech can ensure the excellent consistency of OsrHSA from different batches.

OsrHSA has gained the DMF from US FDA, which showed that the OsrHSA has good safety and tolerance.