Oryzogen Rice Derived Recombinant Human Serum Albumin CAS 70024-90-7

Oryzogen Recombinant Human Serum Albumin derived from rice

Description

Human serum albumin (HSA) is the most abundant protein in plasma synthesized by hepatic parenchymal cells in human body, accounting for about 40%–60% of total protein in plasma with a concentration of 35–50 g/L and a long half-life of 19 days. It consists of a single non-glycosylated polypeptide chain of 585 amino acids forming a heart-shaped molecule with molecular weight of 66.5 kDa and comprising three domains. In human body, HSA is largely responsible for maintaining normal osmolarity in the bloodstream but also functions as a carrier for numerous small molecules. Clinically, HSA is used to treat acute shock, extensive burn, cirrhotic ascites and hemorrhoea.

To date, HSA has been produced by fractionation of human plasma. As the source of the blood can vary, there is the potential risk of HSA contamination by blood-derived pathogens. Human plasma is also in limited supply, recombinant human serum albumin(rHSA) becomes an alternative industrial production which greatly compensates for the shortage of HSA supply.

Wuhan Healthgen Biotechnology Corp.(Healthgen Biotech), a high-tech enterprise specializing in plant-derived pharmaceutical research and development, has successfully developed a series of pharmaceutical products, plant-derived Recombinant Human Serum Albumin(OsrHSA) as the representative, by its two-core patented technology platform: rice endosperm specific expression platform(Oryz^HiExp) and proteins purification platform(Oryz^Pur).

OsrHSA is a recombinant human serum albumin expressed from rice. Why do we choose rice to express and produce human serum albumin? ----Rice has many advantages compared to yeast or other genetic recombination production methods:

1) High expression Level. Patented promotor enables the expression level is 10~1000 times higher over other expression system.

2) Easily scaled-up (High capacity). The host rice is scaled up by farming, and purified recombinant proteins can reach kilo grams level easily.

3) Chemical defined. Free of animal or human-origin pathogens, can eliminate or reduce the potential risk of viruses and other unknown factors in blood derived products.

4) Environmentally friendly. No release of CO₂ or sewage.

5) Simplify downstream process. There are only four main kinds of proteins in rice seed except starch, which can simplify production processing.

6) Non-hazardous. Rice as a kindly of staple food for thousands of years, which is easy to be accepted by the human body.

In summary, by expressing OsrHSA from rice, Healthgen Biotech can easily overcome the difficult of the potential risk of HSA contamination by blood-derived pathogens, and at the same time solve the problem of shortage HSA supply caused by insufficient blood sources.