Oryza Sativa Recombinant HSA Derived From Plant Non Animal Component RecHSA

Recombinant human serum albumin HSA derived from plant non Animal Component

Quick Details

CAS No.: 70024-90-7

Other Names:Recombinant HSA, rHSA, OsrHSA

EINECS No.: 274-272-6

Purity: Greater than 99 % as determined by SDS-PAGE

Source: Rice Grain (Oryza Sativa)

Formulation: OsrHSA is lyophilized without stabilizer or surface active agent

Endotoxin: Less than 0.125EU/mg

Storage and Handling: Stored at temperatures 2-8℃ for 48 months

Description

Human serum albumin is the most abundant protein in human plasma. It can transport hormones, lipds and other molecules and maintain osmotic pressure. Animal free rHSA is a recombinant human serum derived from rice grains, and doesn't contain any animal component, which is much safer than plasma derived HSA.

Human serum albumin is derived from human plasma, which is collected from different human bodies. So we cannot guarantee the stability of human serum albumin from different batches. Because of this, it is difficult to apply to large-scale application in vaccine production and cell culture. However, Healthgen Biotech uses State-of-the-art platform, having high capacity to express proteins and peptides in the rice grain. The platform uses rice endosperm cells as a bioreactor to specifically and highly express various recombinant proteins and small peptides. By using homozygous rice as the raw material, with the world's top production process, Healthgen Biotech can maximize the stability of albumin batches to meet the needs of industrial production.

Physiological and Biochemical Properties of rHSA and pHSA

Supplemental Description

Wuhan Healthgen Biotechnology Corp. has been committed in research of protein purification, meanwhile our technology has been patented by the US Patent and Trademark Office on May 15th 2015 and been granted the patent of "A method for isolating and purifying recombinant human serum albumin from transgenic rice grain", which patent number is US9, 023,990. Now, our OsrHSA purity can be higher than 99%.

Based on the innovative technology, Healthgen Biotech also published research papers.

Publications

1. He Y, et al. Large-scale production of functional human serum albumin from transgenic rice seeds. Proc Natl Acad Sci USA. 2011;108:19078-19083.

2. Zhen Chen, et al. Human serum albumin from recombinant DNA technology: challenges and strategies. Biochimica et Biophysica Acta. 2013; 1830: 5515-5525.

3. Zhen Chen, et al. Quantitation of the residual DNA from rice-derived recombinant human serum albumin. Analytical Biochemistry. 2014; 450: 4-10.

4. Jiquan Ou, et al. Transgenic rice endosperm as a bioreactor for molecular pharming. Plant Cell Rep (2014) 33:585–594

5. Kai fu, et al. Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells. PLoS ONE 01/2014; 9(8): e104426.