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| Source: | Rice Grain （Oryza Sativa） | Molecular Weight: | 66.5kD |
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| Purity: | Great Than 99% | Physical Appearance: | Off-white To Light Beige Lyophilized Powder |
| Storage Condition: | Stored At Temperatures 2~8℃ | Production Type: | Recombinant Protein |
| Highlight: | Lyophilized Powder Recombinant Human Serum Albumin,High Purity Recombinant Human Serum Albumin |
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High purity and lyophilized powder recombinant human serum albumin with animal component free
Description
Human serum albumin (HSA) is a soluble, globular, and unglycosylated monomeric protein; it functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones, and plays an important role in stabilizing extracellular fluid volume. HSA is widely used clinically to treat serious burn injuries, hemorrhagic shock, hypoproteinemia, fetal erythroblastosis, and ascites caused by cirrhosis of the liver.
The market demand for HSA is estimated at more than 500 tons per year worldwide. Because of the shortage and contaminants risks of plasma, the development of a low-cost method for the production of recombinant HSA (rHSA) is essential as a safer and potentially unlimited alternative to pHSA.
Healthgen Biotech has developed the rice endosperm cell expression platform (OryzHiExp), which has such advantages: high expression level, safety, scale-up easily, simple production process and environmental protection etc. Using this advanced technology, Healthgen Biotech expressed and purified the human serum albumin (rHSA) from rice grain. The rHSA has high purity, more than 99%, and low endotoxin, less than 0.125EU/mg, and is animal origin free, which effectively avoid any potential risk of animal contaminants, bacteria, prions, virus and contagious protein disease.
Physiological and Biochemical Properties of rHSA and pHSA are showed as below:
| Char. | pHSA | rHSA |
| Amino Acids Sequence | Same | Same |
| N-terminus | DAHKSEV | DAHKSEV |
| C-terminus | KLVAASQAALGL | KLVAASQAALGL |
| Glycosylation | No | No |
| Molecular Mass(MALDI) | 66.554KD | 66.550KD |
| PI | 4.8 | 4.8 |
| Drug Binding | Similar | Similar |
| Thermal Stability | M/P 65℃ | M/P 65℃ |
| Lipid Conjugation | Identical | Identical |
| Crystal Structure | Identical | Identical |
Supplemental Description
The technology and rHSA have been granted with 16 international patents, covering countries, such as United States, Japan, Europe, Canada and South Africa. Parts of the patents are showed as below:
A callus-specific promoter of rice and the use thereof
China patent no. 201110054109.X
Method for expressing small peptides using cereal non-storage proteins as fusion carrier in endosperm and the use thereof
US patent no. US20070289033
Japan patent no. JP2007-325594A
Europe patent no. EP1865064
Canada patent no. CA2587092
China patent no. 200610019285.9
A method for extracting recombinant human serum albumin from transgenic rice grain
South Africa patent no. 2013/04359
China patent no. 201010597544.2
A method for isolating and purifying recombinant human serum albumin from transgenic rice grain;
South Africa patent no. 2013/04358
China patent no. 201010606635.8
A method for isolating and purifying recombinant human serum albumin from transgenic rice grain
South Africa patent no. 2013/04358
US patent no. US9023990 B2
Production of recombinant human serum albumin with rice endosperm cells as biological reactor
China patent no. ZL 2005 1 0019084.4
Contact Person: Ms. Abby
Tel: +86-15071115810
Fax: 86-27-59403933-59416006
| Factory Address:268 Shendun 5th Road, East Lake High-Tech Development Zone, Wuhan, China 430020 | |
| Sales office:268 Shendun 5th Road, East Lake High-Tech Development Zone, Wuhan, China 430020 | |
| +86-27-59301891-8015 | |
| caojing@oryzogen.com | |
