Greater Than 99% Purity Recombinant HSA rHSA Stabilizer Without Animal Components

Greater Than 99% Purity Recombinant Human Serum Albumin rHSA Stabilizer Without Animal Components

Quick detail

1. CAS No.: 70024-90-7
2. Other Names: Recombinant HSA, rHSA, OsrHSA
3. Amino Acids Sequence: Same as the HSA from plasma
4. N-terminus: DAHKSEV
5. C-terminus: KLVAASQAALGL
6. Glycosylation: No
7. PI: 4.8
8. Thermal Stability: M/P 65℃
9. Lipid Conjugation:Same as the HSA from plasma
10. Crystal Structure: Same as the HSA from plasma
11. Endotoxin: Less than 0.01EU/mg
12. Storage and Handling: Stored at temperatures 2-8℃ for 60 months

Description

Recombinant human serum albumin (abbreviated as rHAS) is widely used as excipient and stabilizer because of its non-enzymatic activity and non-immunogenicity. In addition, it is also used in pharmaceutical excipients because of its anti-oxidation. The excipient can be used as a carrier in a pharmaceutical formulation which facilitates the formulation of the formulation and has the effect of increasing the stability of the drug, altering the absorption of the drug, increasing the bioavailability, controlling the drug release rate and release site and increasing acceptability. The half-life of rHSA is as long as 19 days, which can lengthen the half-life of the drug, pharmaceuticals or vaccine and maintain their activity and stability.

Advantages 

1. The chairman of Healthgen Biotech Professor Daichang.Yang is one of China's chief scientists. Professor Yang has rechieved the “Thousand Talents program” of the National Central Organization Department, "Hundred Talents Program" of the Organization Department of Hubei Province and Top 10 "Venture Eagle" entrepreneurs.

With years of effort, Healthgen Biotech has developed the State-of-the-Art platform called Oryz^HiExp, having high capacity to express no animal origin proteins and peptides in the rice endosperm cells.

2. Healthgen Biotech quality control systerm has been certified by ISO 9001:2015 and ensure standardized process as well as qualified products.

3. Healthgen Biotech recombinant human serum albumin(OsrHSA) is free of animal origin, which effectively avoid any potential risk of animal bacteria, prions, virus and contagious protein disease.

Supplemental Description

The research results have been granted with 16 international patents, covering countries, such as United States, Japan, Europe, Canada and South Africa. Parts of the patents are showed as below:

A callus-specific promoter of rice and the use thereof

China patent no. 201110054109.X

Method for expressing small peptides using cereal non-storage proteins as fusion carrier in endosperm and the use thereof

US patent no. US20070289033

Japan patent no. JP2007-325594A

Europe patent no. EP1865064

Canada patent no. CA2587092

China patent no. 200610019285.9

A method for extracting recombinant human serum albumin from transgenic rice grain

South Africa patent no. 2013/04359

China patent no. 201010597544.2

A method for isolating and purifying recombinant human serum albumin from transgenic rice grain;

South Africa patent no. 2013/04358

China patent no. 201010606635.8

A method for isolating and purifying recombinant human serum albumin from transgenic rice grain

South Africa patent no. 2013/04358

US patent no. US9023990 B2

Production of recombinant human serum albumin with rice endosperm cells as biological reactor

China patent no. ZL 2005 1 0019084.4

Based on the innovative technology, Healthgen Biotech also published research papers.

Publications

1. He Y, et al. Large-scale production of functional human serum albumin from transgenic rice seeds. Proc Natl Acad Sci USA. 2011;108:19078-19083.

2. Na An, et al. Expression of a Functional Recombinant Human Basic fibroblast Growth Factor from Transgenic Rice Seeds. Int. J. Mol. Sci. 2013, 14, 3556-3567

3. Liping Z, et al. Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed. Journal of Biotechnology. 2012; 164: 300-308.

4. Xie, T, et al. A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery. Peptides 2008: 29: 1862-1870.

5. Zhen Chen, et al. Human serum albumin from recombinant DNA technology: challenges and strategies. Biochimica et Biophysica Acta. 2013; 1830: 5515-5525.

6. Zhen Chen, et al. Quantitation of the residual DNA from rice-derived recombinant human serum albumin. Analytical Biochemistry. 2014; 450: 4-10.

7. Jiquan Ou, et al. Transgenic rice endosperm as a bioreactor for molecular pharming. Plant Cell Rep (2014) 33:585–594

8. Kai fu, et al. Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells. PLoS ONE 01/2014; 9(8): e104426.