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| Source: | Rice Grain(Oryza Sativa) | Formulation: | No Stabilizer Or Surface Active Agent |
|---|---|---|---|
| Usage: | Cell Culture, Stem Cell Culture, Vaccine Reseach | CAS No.: | 70024-90-7 |
| Sterility Test: | Sterile | Abnormal Toxicity Test: | Conforms To Standard |
| Highlight: | Lyophilized Powder Recombinant HSA,Recombinant HSA ISO,ISO recombinant human serum albumin |
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White to Light Beige Lyophilized Powder Recombinant Human Serum Albumin HSA ISO Certificated
Quick detail
Physiological and Biochemical Properties of rHSA and pHSA
| Char. | pHSA | rHSA |
| Amino Acids Sequence | Same | Same |
| N-terminus | DAHKSEV | DAHKSEV |
| C-terminus | KLVAASQAALGL | KLVAASQAALGL |
| Glycosylation | No | No |
| Molecular Mass(MALDI) | 66.554KD | 66.550KD |
| PI | 4.8 | 4.8 |
| Drug Binding | Similar | Similar |
| Thermal Stability | M/P 65℃ | M/P 65℃ |
| Lipid Conjugation | Identical | Identical |
| Crystal Structure | Identical | Identical |
Description
Healthgen Biotech has committed to albumin research for 10 years and has successfully developed and manufactured high-quality rHSA. We have excellent albumin sources, which are derived from rice endosperm cells; Our scale production facility is compliant with GMP.We have highly-sophisticated protein purification technology. Our quality control systerm has been certified by ISO 9001:2015 and ensure standardized process as well as qualified products. We can provide large-scale, high-quality and high batches stability albumins. The rHSA has been registered in US FDA as DMF.The DMF no. is 029 648.
Advantages
The research results have been granted with 16 international patents, covering countries, such as United States, Japan, Europe, Canada and South Africa. Parts of the patents are showed as below:
A callus-specific promoter of rice and the use thereof
China patent no. 201110054109.X
Method for expressing small peptides using cereal non-storage proteins as fusion carrier in endosperm and the use thereof
US patent no. US20070289033
Japan patent no. JP2007-325594A
Europe patent no. EP1865064
Canada patent no. CA2587092
China patent no. 200610019285.9
A method for extracting recombinant human serum albumin from transgenic rice grain
South Africa patent no. 2013/04359
China patent no. 201010597544.2
A method for isolating and purifying recombinant human serum albumin from transgenic rice grain;
South Africa patent no. 2013/04358
China patent no. 201010606635.8
A method for isolating and purifying recombinant human serum albumin from transgenic rice grain
South Africa patent no. 2013/04358
US patent no. US9023990 B2
Production of recombinant human serum albumin with rice endosperm cells as biological reactor
China patent no. ZL 2005 1 0019084.4
Based on the innovative technology, Healthgen Biotech also published research papers.
Publications
1. He Y, et al. Large-scale production of functional human serum albumin from transgenic rice seeds. Proc Natl Acad Sci USA. 2011;108:19078-19083.
2. Na An, et al. Expression of a Functional Recombinant Human Basic fibroblast Growth Factor from Transgenic Rice Seeds. Int. J. Mol. Sci. 2013, 14, 3556-3567
3. Liping Z, et al. Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed. Journal of Biotechnology. 2012; 164: 300-308.
4. Xie, T, et al. A biologically active rhIGF-1 fusion accumulated in transgenic rice seeds can reduce blood glucose in diabetic mice via oral delivery. Peptides 2008: 29: 1862-1870.
5. Zhen Chen, et al. Human serum albumin from recombinant DNA technology: challenges and strategies. Biochimica et Biophysica Acta. 2013; 1830: 5515-5525.
6. Zhen Chen, et al. Quantitation of the residual DNA from rice-derived recombinant human serum albumin. Analytical Biochemistry. 2014; 450: 4-10.
7. Jiquan Ou, et al. Transgenic rice endosperm as a bioreactor for molecular pharming. Plant Cell Rep (2014) 33:585–594
8. Kai fu, et al. Immunotoxicity assessment of rice-derived recombinant human serum albumin using human peripheral blood mononuclear cells. PLoS ONE 01/2014; 9(8): e104426.
Contact Person: Ms. Abby
Tel: +86-15071115810
Fax: 86-27-59403933-59416006
| Factory Address:268 Shendun 5th Road, East Lake High-Tech Development Zone, Wuhan, China 430020 | |
| Sales office:268 Shendun 5th Road, East Lake High-Tech Development Zone, Wuhan, China 430020 | |
| +86-27-59301891-8015 | |
| caojing@oryzogen.com | |
